Diagnostic des syndromes lymphoprolifératifs chroniques

Abstract

Chronic lymphoproliferative syndromes represent a relatively heterogeneous group of malignant haemopathies in which mature B- and T-cells, as well as other cells of similar lineages, such as NK-cells, are affected. The point of grouping them together lies in their common diagnostic procedure, which leads to the identification of the malignant population, based on clinical and biological symptoms. These symptoms are anomalies in haemograms, myelograms or peripheral lymphoid organs. A biological multidisciplinary organisation allows the gathering of the information necessary to the precise definition of the disease as well as the prognostic factors likely to influence the course of the treatment. The chronic evolution of these affections, the frequently iterative recurrences and complications are a serious problem despite the usually slow tumor progression. The most frequent complications are linked to medullar insufficiency, infections due to the immune deficiency, auto-immune manifestations, the pathogenicity of the splenomegaly and the transformation to high-grade malignant lymphoma (Richter syndrome).