Abstract
Hepatorenal syndrome (HRS) is a variant of functional renal failure in acute or chronic liver pathology. Type 1 HRS entails a rapidly progressive decline in kidney function within few days and without liver transplantation, 95,0 % of patients die within the next few weeks. With type 2 HRS, kidney function remains stable or gradually declining over several months. HRS diagnosis is based on the exclusion of other causes of renal failure. Pathophysiological changes in renal failure in the case of HRS are quite complex – they include an increase in the synthesis of vasoactive substances, which lead to a decrease in renal perfusion, a decrease in resistance in peripheral arteriovenous anastomosis, the development of portal hypertension, ascites, a decrease in colloidal osmotic pressure and a consistently increasing delay of sodium and water in the kidneys. HRS therapy is based on acid-base balance and anemia correction, intravenous administration of albumin, paracentesis, the removal of nephrotoxic agents and the renal replacement therapy is only symptomatic. areast-font-family:Times New Roman;mso-bidi-font-family:Times New Roman; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'>, 420012
Highlights
Type 1 Hepatorenal syndrome (HRS) entails a rapidly progressive decline in kidney function within few days and without liver transplantation, 95,0 % of patients die within the few weeks
HRS diagnosis is based on the exclusion of other causes of renal failure
Pathophysiological changes in renal failure in the case of HRS are quite complex – they include an increase in the synthesis of vasoactive substances, which lead to a decrease in renal perfusion, a decrease in resistance in peripheral arteriovenous anastomosis, the development of portal hypertension, ascites, a decrease in colloidal osmotic pressure and a consistently increasing delay of sodium and water in the kidneys
Summary
Гепаторенальный синдром (HRS) является вариантом функциональной почечной недостаточности при острой или хронической патологии печени. При HRS 1 типа почечная функция ухудшается за несколько дней и без трансплантации печени 95,0 % пациентов умирают в течение ближайших недель. При HRS 2 типа функция почек остается на стабильном уровне либо наблюдается постепенное ее снижение на протяжении нескольких месяцев.
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