Abstract
Abstract Microscopy enables fast and effective diagnostics. However, in resource-limited regions microscopy is not accessible to everyone. Smartphone-based low-cost microscopes could be a powerful tool for diagnostic and educational purposes. In this paper, the imaging quality of a smartphone-based microscope with four different optical parameters is presented and a systematic overview of the resulting diagnostic applications is given. With the chosen configuration, aiming for a reasonable trade-off, an average resolution of 1.23 μm and a field of view of 1.12 mm2 was achieved. This enables a wide range of diagnostic applications such as the diagnosis of Malaria and other parasitic diseases.
Highlights
Microscopy is an important tool for science and medicine
With the smallest resolvable element, the arithmetic mean of the Michelson contrast was calculated for each smartphone-based microscope
The use of the Samsung Galaxy S4 front camera lens resulted in the highest resolution
Summary
Microscopy is an important tool for science and medicine. It is considered the gold standard for numerous diseases. In many resource-limited regions, microscopy equipment is not available. Smartphonebased low-cost microscopes have the potential to enable microscopy diagnostics in these regions. Smartphones are very abundant and there will be an estimated number of 6.4 billion smartphones in the world by 2021 [1]. The integrated smartphone camera systems have improved significantly in recent years, resulting in the possibility of developing high-resolution smartphone-based microscopes with an advanced but low-cost optical system. To be an adequate replacement for conventional laboratory microscopes the resolution of a smartphone-based microscope
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