Abstract
Diabetes mellitus (DM) is a chronic disease that occurs due to inadequate production of insulin or decreased effect of available insulin. Considered one of the most critical life-threatening diseases of the 21st century, the number of patients has been increasing over the past few decades. These patients suffer many problems such as neuropathy, nephropathy and rethinopathy which the first can decrease their life expectations. Diabetic peripheral neuropathy (DPN) is the most common complication in diabetic patients and more than one half of these patients develop nerve dysfunction through their life. The primary cause of diabetic foot disease is DPN which sleep disturbances, poor quality of life, depression and finally unemployment are the results of it. In this article, we are studying different biomarkers of diabetic neuropathy using related papers in order to consider them in diabetic patients and prevent further complications in them.
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