Diagnostic biomarkers and aortic dissection: a systematic review and meta-analysis

Abstract

BackgroundAortic dissection (AD) is a serious and fatal vascular disease. The earlier the condition of AD patients can be assessed precisely, the more scientifically controlled the patient’s condition will be. Therefore, timely and accurate diagnosis is significant for AD. Blood biomarker testing as a method of liquid biopsy can improve the diagnostic efficiency of AD. This study conducted a systematic review of the current blood diagnostic biomarkers of AD.MethodsThe PubMed, Cochrane Library, Web of Science, and Embase electronic databases were systematically searched from inception to January 1, 2023, using the terms “aortic dissection”, “serum”, “plasma” and “diagnosis”. Stata 12.0 software was used to perform Random effects meta-analysis was performed using Stata 12.0 software to determine the effect sizes and corresponding 95% confidence intervals. Then, a summary receiver operator characteristic (SROC) curve was drawn, and the area under the ROC curve (AUC) was calculated.ResultsD-dimer had the best sensitivity and AUC for AD, with values of 0.96 (95% CI: 0.93–0.98) and 0.95 (95% CI: 0.93–0.97), respectively. The sensitivity and AUC values for D-dimer with a cut-off value of 500 ng/mL were 0.97 (95% CI: 0.95–0.99) and 0.94 (95% CI: 0.92–0.96), respectively. In contrast, microRNA had a better specificity value for AD, at 0.79 (95% CI: 0.73–0.83).ConclusionsD-dimer and microRNA have good accuracy in the diagnosis of AD, but the specificity of D-dimer is worse, and studies of microRNA are insufficient. The combination of different biomarkers can improve the diagnostic accuracy. Other blood biomarkers are related to the pathological progression of AD and can be selected according to pathological progress.