Abstract
Median age at presentation was 76 (71-80) years old. TUG (p 0.05). LP log improvement was associated with surgical indication OR: 24.5 95%CI (2.4248.12) (p=0.007). Conclusions LP log showed a higher sensitivity and diagnostic accuracy detecting clinical differences in NPH than the current diagnostic approach. Our next step is to conduct a cross-validation analysis of the diagnostic and prognostic accuracy of this new tool.
Highlights
Treatment in Normal Pressure Hydrocephalus (NPH) yields better post-operative outcomes
We prospectively studied 62 consecutive new patients with suspected idiopathic NPH
Lumbar Puncture (LP) log score is recorded at baseline and for 7 consecutive days after removing 40 cc of CSF via LP
Summary
Treatment in Normal Pressure Hydrocephalus (NPH) yields better post-operative outcomes. Our current tests often fail to detect significant changes at early stages. We developed a new scoring system (LP log score) and sought a “proof of concept” that this tool is more sensitive in detecting clinical differences than the current ones
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