Abstract
Canine pancytopenia in the peripheral blood is often the result of monocytic ehrlichiosis (Ehrlichia canis), parvoviral enteritis, sepsis and the use of various drugs (antineoplastic, nonsteroidal anti-inflammatory, antimicrobial, antiparasitic, antiepileptic, estrogens) accounting for bone marrow hypoplasiaaplasia. Sporadic cases of pancytopenia, induced by neoplastic myelophthisis, myelodysplastic and hemophagocytic syndromes, myelofibrosis, myelonecrosis and systemic lupus erythematosus may also be seen. A comprehensive diagnostic plan may include a detailed history (i.e. recent drug exposure), a thorough clinical examination, complete blood count, routine serum biochemistry and the microscopic examination of peripheral blood smears, to rule out false thrombocytopenia or leukopenia and to search for E canis morulae, leukemic cells and toxic neutrophilic changes. However, the diagnostic cornerstone in the pancytopenic dog is bone marrow cytology, for the undisputable differentiation between myelosuppressive and non-myelosuppressive monocytic ehrlichiosis and the confirmation of hemopoietic tumors, myelodysplastic or hemophagocytic syndromes and bone marrow aplasia. Bone marrow core biopsy and histopathology is the method of choice for the definitive diagnosis of myelofibrosis, myelonecrosis and occasionally of bone marrow aplasia. Also, serology for E canis and antinuclear antibodies and fecal ELISA for parvovirus antigen are strongly recommended, along with the application of various imaging techniques, especially for the detection of ovarian tumors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of the Hellenic Veterinary Medical Society
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.