Abstract
Polymerase chain reaction analysis applied in amniotic fluid has represented a major breakthrough for a more accurate, safe, simple and rapid result of prenatal diagnosis of congenital toxoplasmosis. However, given the limited but significant risk of fœtal loss associated with amniocentesis, such indication should be restricted to documented or highly suspected cases of maternal infections as assessed by appropriate serological methods and screening strategies during pregnancy. Knowledge of risks of transmission and infectious sequelae according to gestational age at maternal infection is also required for decisions of prenatal diagnosis as well as interpretation of results of PCR in amniotic fluid. In all cases of a negative PCR result, only a serological post-natal follow-up can rule out congenital infection.
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