Diagnostic and Therapeutic Value of Procalcitonin and D-dimer in Sepsis Study on the Expression of Procalcitonin (PCT) and D-dimer (D-D) in Serum of Sepsis Patients and Their Correlation

Abstract

Altogether 89 septic patients admitted to our hospital from February 2018 to March 2019 were selected as the experimental group, and 60 healthy people underwent physical examination during the same period were selected as the control group. The expression of PCT and D-D in serum was detected by enzyme-linked immunosorbent assay (ELISA), and the diagnostic value of PCT and D-D in septic patients was evaluated by receiver operating characteristic curve (ROC). Peason correlation coefficient was used to analyze the correlation between PCT and D-D, and the correlation among inflammatory factors interleukin-6 (IL-6), platelet activating factor (PAF), tumor necrosis factor -α (TNF-α). Logistic regression was used to analyze the independent risk factors affecting the onset of sepsis. The expressions of serum PCT and D-D in septic patients were higher than those in the control group. AUC of patients with sepsis diagnosed by serum PCT and D-D were 0.929 and 0.905. The expression of IL-6, PAF and TNF-α in the experimental group was significantly higher than that in the control group. There was a positive correlation between PCT and D-D in the experimental group, and a positive correlation of PCT, D-D with IL-6, PAF and TNF-α. Patients with old age, high lactic acid, high CRP, high urea nitrogen, high serum creatinine, high PCT and high D-D expression have an increased risk of sepsis. Our study showed that the expression of PCT and D-D increases in septic patients, which has a satisfactory diagnostic value for septic patients, and inhibition of PCT and D-D expression can be used as a potential therapeutic target for septic patients.