Diagnostic and Therapeutic Model of Sepsis and Purulent-Inflammatory Diseases

Lesia Ostapiuk

doi:10.4236/ijcm.2019.1011047

Abstract

In this study, the method of fluorescence spectroscopy was used to improve the diagnostics and prediction of sepsis, pyo-inflammatory diseases and postpartum endometritis. At the first stage of the study, the researcher explored the fluorescence spectra of dilutions of serum with centrifuged and non-centrifuged bacterial culture (6-day crop sugar broth with Staphylococcus aureus), distilled water, 20% albumin and sugar broth. The focus was on the influence of treatment, including infusion therapy, on the fluorescence spectral characteristics of a patient’s serum. At the second stage, the method of fluorescence spectroscopy was used for the diagnosis of sepsis in vivo. At the third stage, the analyst scrutinized the peculiarities of pregnancy, childbirth, and the postpartum period (totally, 40 parameters) in patients with postpartum pyo-inflammatory diseases and in the control group.

Highlights

Despite an in-depth attention to the global epidemiological problem of sepsis, it has not been fully resolved yet
As patients improve, changes in the spectral-fluorescence characteristics of blood serum (BS) occur in reverse order: there is an increase in the fluorescence intensity of the main peak, and the “septic peak” gradually shifts into the short-wave region and gradually disappears
We focused on the study of spectral-fluorescence features of the pathognomic pathogenic for sepsis pathological constellation serum + bacterium − the phenomenon of bacteremia

Summary

Introduction

Despite an in-depth attention to the global epidemiological problem of sepsis, it has not been fully resolved yet. The focus has been on the selection of effective antibiotic regimens and other aspects of treatment. The microscopic mechanisms of the aetiology and pathogenesis of sepsis have not been debated satisfactorily. It develops in over 30 million people annually and kills over 6 million out of them [1]. The prevalence of sepsis is the highest in lowand middle-income countries. Every year 3 million newborns and 1.2 million children suffer from sepsis [2].

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Conclusion