Abstract
BackgroundTo investigate the value of anti‐helicobacter pylori (Hp) antibody, serum carbohydrate antigen (CA)‐724, CA19‐9, and carcinoembryonic antigen (CEA) in the diagnosis and prognosis evaluation of young patients with early gastric cancer.MethodsA total of 200 young patients with gastric cancer from April 2014 to December 2015 were enrolled. A total of 206 patients with gastritis and 204 healthy subjects were also selected. Gastric cancer patients were followed up for 3 years, and the number of recurrences, metastasis, and death was recorded.ResultsThe positive rate of anti‐Hp antibody, CA724, CA19‐9, and CEA in young patients with early gastric cancer were significantly higher than those in gastritis and healthy subjects (P < .05), and was positively correlated with tumor stage, tumor size, and lymph node metastasis (P < .05). The predicting model was as follows: Logit (P) = 26.433‐3.014(CA724)‐3.908(CA19‐9)‐0.303(CEA)‐2.208(anti‐Hp antibody, Positive = 1; Negative = 0). This model had a high value in identifying young patients with early gastric cancer with AUC of 0.918, and the estimated probability was .806. Compared to patients with negative anti‐Hp antibody and low serum levels of CA724, CA19‐9, and CEA, the recurrence rate, metastasis rate, and mortality of patients with positive anti‐Hp antibody, high serum levels of CA724, CA19‐9, and CEA increased significantly (P < .05).ConclusionThis study indicated that anti‐Hp antibody combined with CA724, CA19‐9, and CEA had important value in the identification of young patients with early gastric cancer and were of great value in evaluating the risk of postoperative recurrence, metastasis, and death.
Highlights
Gastric cancer is a common malignant tumor, ranking fourth in the incidence of all global malignant tumors, and is a serious threat to people's health.[1]
Correlation analysis showed that anti-helicobacter pylori (Hp) antibody positive rate and serum carbohydrate antigen-724 (CA724), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) levels had no significant correlation with age, gender, differentiation status, and tumor type of young patients of gastric cancer (P > .05, Tables 2 and 3, and Table S1)
With the emphasis on gastric cancer and the adjustment of dietary structure, the incidence of this disease has decreased slightly overall, but the new cases have gradually shown a trend of youthfulness, which is a huge threat to human health
Summary
Gastric cancer is a common malignant tumor, ranking fourth in the incidence of all global malignant tumors, and is a serious threat to people's health.[1]. A large number of clinical data and references showed that young gastric cancer had more specific clinical manifestations than middle-aged gastric cancer, with a higher degree of malignancy, earlier metastasis, and poorer prognosis.[7,8]. Studies had shown that the 5-year survival rate of early gastric cancer surgery could reach more than 90%, while the 5-year survival rate of postoperative gastric cancer is only 5%-15%.9. In this case, it is worthwhile to improve the early diagnostic methods for young patients with early gastric cancer. This article selected healthy controls, patients with gastritis, and young patients with early gastric cancer, to explore the diagnostic and prognostic values of anti-Hp antibody, CA724, CA19-9, and CEA in young patients with early gastric cancer
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