Abstract
Metastasis-associated in colon cancer-1 (MACC1) promotes colorectal cancer progression and predicts prognosis. The aim of our study was to determine the diagnostic and prognostic value of preoperative serum MACC1 levels in breast cancer patients. Serum MACC1 levels were measured in 378 breast cancer patients, 120 patients with benign breast disease, and 40 healthy volunteers using an ELISA. Serum MACC1 levels were higher in breast cancer patients than patients with benign disease or healthy volunteers. Increased serum MACC1 was associated with breast cancer TNM stage (P < 0.001), tumor size (P < 0.001), lymph node metastasis (P < 0.001), and Ki-67 status (P = 0.014). Serum MACC1 measurement successfully discriminated breast cancer patients from normal and healthy controls (AUC = 0.785, 95% CI: 0.746–0.825) with an optimal cut-off value of 38.35 pg/ml (sensitivity = 0.725, specificity = 0.696). Moreover, serum MACC1 exhibited significant prognostic value in breast cancer (AUC = 0.757, 95% CI: 0.700–0.814), and high MACC1 was associated with poor disease-free survival (HR 5.63, 95% CI: 3.51–9.04; P < 0.001). Our findings demonstrated that circulating MACC1 could serve as a reliable diagnostic and prognostic biomarker for breast cancer.
Highlights
Breast cancer (BC) is the most frequently diagnosed cancer and the second leading cause of cancer-related death among American women [1, 2]
We found that serum Metastasis-associated in colon cancer-1 (MACC1) successfully discriminated BC patients from healthy controls (AUC = 0.785, 95% CI: 0.746–0.825)
Serum MACC1 levels were elevated in BC patients compared with patients with benign breast diseases or healthy volunteers
Summary
Breast cancer (BC) is the most frequently diagnosed cancer and the second leading cause of cancer-related death among American women [1, 2]. BC incidence has increased in China in recent decades and outcomes for patients with metastatic disease remain poor, with a median overall survival time of two to three years [3, 4]. A lack of effective treatment options, which rely heavily on timely diagnosis, contributes to poor survival in earlystage BC patients [5]. Novel biomarkers are urgently needed to detect early stage BC. Serum RNAs and proteins found to correlate with tumor status and/or patient survival are increasingly being applied as diagnostic and prognostic indicators in various carcinomas. Detection of circulating proteins represents a promising noninvasive strategy for tumor diagnosis and prognosis, and for monitoring antitumor therapies
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