Abstract

Objective To investigate the diagnostic and prognostic value of N-terminal pro brain natriuretic peptide(NT-proBNP) in patients with chronic heart failure.Methods The plasma levels of NT-proBNP in 95 patients with chronic heart failure and 30 patients who were diagnosed as non coronary heart disease as controls group were detected and the left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter (LVEDD) were measured by cardiac color doppler ultrasound.The occurrence of rehospitalization and death of patients with chronic heart failure was followed-up for 90 days.Results ①The plasma levels of NT-proBNP in patients with chronic heart failure (NYHA Ⅱ-Ⅳ group) who were graded by New York Heart Function Assessment[(1350 ± 204) pg/ml,(2932 ± 483) pg/ml,(7522 ± 952) pg/ml] was significant higher than that of control group [(107 ± 39) pg/ml],LVEDD [(49.5 ± 5.3) mm,(56.6 ± 6.1) mm,(62.4 ± 8.3) mm] was significant higher than that of controls [(44.6 ±3.9)mm],but LVEF[(57.4 ±6.7)％,(50.3 ±9.6)％,(45.2 ± 10.1)％] was significant lower than that of control group [(65.2 ± 4.5) ％].The difference among NYHA Ⅱ group,NYHA Ⅲ group,NYHA Ⅳ group was also statistically significant.②The plasma levels of NT-proBNP in event group were significantly higher than those in non-event group.Conclusions The detection of the plasma levels of NT-proBNP is important for the diagnosis and disease assessment in patients with chronic heart failure,NT-proBNP can provide valuable prognostic information for chronic heart failure. Key words: N-terminal pro brain natriuretic peptide ; Chronic heart failure ; Diagnosis ; Prognosis

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