Abstract
Disorders of the kidneys often occur in cardiovascular diseases. They are connected with the heart by complex hemodynamic and neuroendocrine bonds. The structure, functions, and possibilities of using an endogenous indicator of the functional state of the kidney - cystatin C are discussed in the article. Available data allow the use of cystatin C as a predictor of renal dysfunction in patients with cardiovascular pathology and arterial hypertension, in particular. However, the widespread use of cystatin C in routine clinical practice requires further study and improvement.
Highlights
There are complex hemodynamic and neuroendocrine bonds between the heart and the kidneys, which unite them into a single functional system
In order to evaluate the functional status of the kidneys, clinical definition of glo merular filtration rate (GFR) is most often used in clinical practice, but its reduction only occurs when the number of functioning nephrons decreases, it cannot serve as an early marker of kidney damage, which became the prerequisite for the search for more sensitive diagnostic methods [39]
It has been shown that Cys Cis a more sensitive indicator of GFR lowering than creatinine because it is not influenced by such factors as age, gender, muscle mass, nutritional characteristics, physical activity, race
Summary
There are complex hemodynamic and neuroendocrine bonds between the heart and the kidneys, which unite them into a single functional system. Diagnostic and prognostic value of cystatin C as an early marker of renal dysfunction in patients with cardiovascular pathology
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