Diagnostic and economic efficiency of schemes for differential diagnosis of chronic hepatitis and liver cirrhosis, based on the determination of interleukin-13, alpha-1-defensin and enzymatic activities in serum

Abstract

The search for non-invasive criteria for the differential diagnosis of chronic hepatitis and liver cirrhosis is one of the urgent tasks of hepatology. Purpose: to evaluate the diagnostic and economic efficiency of differential diagnostic schemes for the determination of chronic hepatitis and liver cirrhosis of alcoholic and unspecified etiology, based on the determination of interleukin-13, alpha-1-defensin and enzymatic activities in blood serum. Material and method: The study included 41 patients with chronic hepatitis, 102 patients with liver cirrhosis of alcoholic and unspecified etiology. The control group included 43 donors from the blood transfusion station. The levels of enzymatic activities, interleukin-13 and alpha-1-defensin of blood serum were determined. Results: Hyaluronidase and elastase activities, as well as serum interleukin-13 and alpha-1-defensin, showed high diagnostic efficiency in detecting chronic diffuse inflammatory liver diseases, and trypsin-like and deoxyribonuclease activities in differential diagnosis of chronic hepatitis and liver cirrhosis. The developed differential diagnostic schemes allow differentiating chronic hepatitis and liver cirrhosis with a high odds ratio and have a high economic effect in comparison with Fibrotest and liver biopsy. The inclusion of interleukin-13 and alpha-1-defensin in the examination scheme allows to increase the diagnostic efficiency. Conclusions: Schemes for the differential diagnosis of chronic hepatitis and liver cirrhosis based on enzymatic activity, interleukin-13 and alpha-1-defensin of blood serum allow to improve the results of diagnostic measures, and also have a high economic effect in comparison with Fibrotest and liver biopsy.