Abstract
COVID-19 is the infection caused by the new coronavirus. Specific treatment for COVID-19 has not been established, yet. It is important to determine the disease severity of the patients at the first admission. Therefore, the exploration of biomarkers is deemed necessary. We aimed to assess the diagnostic and early prognostic value of CRP and LDH levels in possible COVID-19 patients presenting with a severe clinical picture. We evaluated the correlations of relevant routine laboratory test results with disease severity in COVID-19 patients admitted to our infectious diseases clinic. Patients were divided into severe and non-severe disease groups based on clinical findings, oxygen saturation levels in the arterial blood, biochemical test results, and radiological findings. Differences in the findings between the two disease severity groups were examined to determine potential biomarkers. Median age and the CRP and LDH levels in the severe disease group were statistically significantly higher compared to the nonsevere group (p < 0.0001). No other parameters statistically significant differences have been observed between the two groups (P > 0.05). CRP and LDH levels were positively correlated with lung lesions in early-stage COVID-19, potentially reflecting disease severity. Because LDH and CRP levels can potentially reflect the pulmonary function, they can be potential predictors of COVID-19- related respiratory failure. For avoiding poor prognosis; LDH and CRP should be considered as potential predictors for identifying the need for thoracic CT scans, close monitoring of pulmonary function, and aggressive supportive therapy early in the course of COVID-19.
Highlights
COVID-19 is the infection caused by the new coronavirus
In identifying patients with severe disease; the Receiver operating characteristic (ROC) curves showed that age had 72% sensitivity and 71% specificity (AUC: 0.78, p < 0.0001) (Figure 1 and 2), C-reactive protein (CRP) levels had 72% sensitivity and 71% specificity (AUC: 0.78, p < 0.0001) (Figures 3 and 4), and lactate dehydrogenase (LDH) levels had 75% sensitivity and 70% specificity (AUC: 0.76, p < 0.0001) (Figures 5 and 6)
Our study results show that increased CRP and LDH levels are significantly associated with disease severity
Summary
COVID-19 is the infection caused by the new coronavirus. Specific treatment for COVID-19 has not been established, yet. We aimed to assess the diagnostic and early prognostic value of CRP and LDH levels in possible COVID-19 patients presenting with a severe clinical picture. Conclusions: CRP and LDH levels were positively correlated with lung lesions in early-stage COVID-19, potentially reflecting disease severity. Various subtypes of coronaviruses that can be transmitted from person to person have been identified in humans Such subspecies mostly cause common colds in humans. Many coronavirus subtypes are detected in animals, causing severe diseases in humans via animal to human transmission [1,2]. The most recently identified coronavirus causing severe infections in humans and becoming a global health issue has been announced by the World Health Organization (WHO) on December 31, 2019, as a new coronavirus (2019-nCoV) that occurred for the first time in China. Starting from the detection of the first case, the approach of our country’s administrative
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