Diagnostic Algorithm for Kawasaki Disease in Febrile Children

Abstract

Ling XB, Kanegaye JT, Ji J, et al. Point-of-care differentiation of Kawasaki disease from other febrile illnesses. J Pediatr. 2013; 162 (1): 183– 188; doi: 10.1016/j.jpeds.2012.06.012[OpenUrl][1][CrossRef][2][PubMed][3] Investigators from Stanford University and the University of California at San Diego studied the pattern of clinical findings and laboratory test results in prospective cohorts of febrile children to develop and validate an algorithm to differentiate Kawasaki disease (KD) from other febrile illnesses. They postulated that such an algorithm could be incorporated into information technologies as an inexpensive point-of-care tool to assist clinicians in diagnosing KD. Four cohorts of children were randomized: children thought to have KD for the training phase (development of the algorithm) (n=276); children with fever not due to KD (febrile controls [FC]) for the training phase (n=243); children thought to have KD for the testing phase (to validate the algorithm internally) (n=136); and FC for the testing phase (n=121). The KD cohorts included children diagnosed within 10 days of fever onset using the American Heart Association guidelines (fever for ≥3 days … [1]: {openurl}?query=rft.jtitle%253DJ%2BPediatr%26rft.volume%253D162%26rft.spage%253D183%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jpeds.2012.06.012%26rft_id%253Dinfo%253Apmid%252F22819274%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/j.jpeds.2012.06.012&link_type=DOI [3]: /lookup/external-ref?access_num=22819274&link_type=MED&atom=%2Faapgrand%2F29%2F4%2F44.atom