Abstract
SOX11 is a transcription factor that is normally expressed in the fetal brain and has also been detected in some malignant tumors, including mantle cell lymphoma (MCL). MCL is a mature B-cell lymphoma that characteristically expresses cyclin D1, which has been used as a diagnostic tumor marker. SOX11 has also recently emerged as a tumor marker for MCL, particularly in cyclin D1-negative MCLs and to distinguish between MCLs and other cyclin D1-positive lymphomas. In this study, we evaluated the diagnostic accuracy of SOX11 immunohistochemistry for the diagnosis of MCL using a meta-analysis. A comprehensive literature search was performed using the PubMED, EMBASE, and Cochrane library through May 9, 2018. In total, 14 studies were included in our meta-analysis. The sensitivity, specificity, and area under the curve calculated from the summary receiver operator characteristic were 0.9, 0.95, and 0.934, respectively. Effect sizes of log positive likelihood ratios, log negative likelihood ratios, and log diagnostic odds ratios were 2.67, -2.12, and 5.27, respectively. Statistically significant substantial heterogeneity was observed for specificity (I2 = 95%), but not for sensitivity. Subgroup analysis and meta-regression were performed to explain the heterogeneity in specificity and showed that the proportions of Burkitt's lymphoma, lymphoblastic lymphoma, and hairy cell leukemia were significant covariates among studies using rabbit polyclonal antibodies. Overall, this meta-analysis showed that SOX11 was a useful diagnostic marker for MCL, with the clone MRQ-58 mouse monoclonal antibody showing particularly robust performance.
Highlights
SOX11 is a transcription factor that is normally expressed in the fetal brain and is thought to play a role in nervous system development.[1]
The results showed that the proportions of Burkitt’s lymphoma (BL), lymphoblastic lymphoma (LBL), and hairy cell leukemia (HCL) were not statistically significant covariates among all studies
The results showed that the proportions of BL, LBL, and HCL were not significant covariates among studies using mouse monoclonal antibodies
Summary
SOX11 is a transcription factor that is normally expressed in the fetal brain and is thought to play a role in nervous system development.[1] SOX11 is expressed in several neoplastic conditions, including ovarian carcinomas, pancreatic solid pseudo-papillary tumor, brain. Diagnostic accuracy of SOX11 in mantle cell lymphoma. No PJ01337701), Rural Development Administration, Republic of Korea to WL. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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