Abstract
BackgroundMultidetector CT (MDCT) has emerged as a useful option for early diagnosis of interstitial lung disease (ILD) with adequate accuracy.MethodsA total of 80 patients with restricted pulmonary functions and clinical suspicion of ILD were enrolled in the study. MDCT evaluation was done using Siemens Somatom Force 384 slice multidetector computer tomography machine. Pattern analysis for reticular opacities, nodules and lung opacities was done to reach at a diagnosis. Final diagnosis was based on correlation of radiological and clinicopathological findings. Diagnostic efficacy of MDCT was evaluated in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detection of ILD.ResultsMean age of patients was 58 ± 8.75 years. Majority were females (51.3%). History of chronic obstructive pulmonary disease (COPD), tuberculosis and bronchial asthma was revealed in 31 (38.8%), 26 (32.5%) and 16 (20%) patients, respectively. There were 30 (37.5%) patients having no history of respiratory diseases. MDCT diagnosed ILD in 45 (56.3%) cases. On final diagnosis, ILD was diagnosed in 35 (43.8%) cases (15 usual interstitial pneumonia [UIP], 9 cryptogenic organizing pneumonia [COP], 8 nonspecific interstitial pneumonia [NSIP] and 3 respiratory bronchiolitis associated interstitial lung disease [RBILD]). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MDCT in detection of ILD was 91.4%, 71.1%, 71.1%, 91.4% and 80%, respectively.ConclusionMDCT as a single modality had a high sensitivity for detection of ILD and could be recommended as first line diagnostic imaging technique.
Highlights
Interstitial lung diseases, known as diffuse parenchymal lung diseases (DPLD), are a group of disorders involving the distal lung parenchyma [1,2]
Diagnostic efficacy of multidetector CT (MDCT) was evaluated in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detection of interstitial lung disease (ILD)
MDCT as a single modality had a high sensitivity for detection of ILD and could be recommended as first line diagnostic imaging technique
Summary
Interstitial lung diseases, known as diffuse parenchymal lung diseases (DPLD), are a group of disorders involving the distal lung parenchyma [1,2]. High-resolution CT (HRCT) of the thorax can provide invaluable information that strongly supports a specific diagnosis and may be diagnostic (e.g., typical changes of Usual Interstitial Pneumonia) such that further testing with bronchoscopy or. How to cite this article Ahmed S, Khanduri S, Husain M, et al (May 23, 2020) Diagnostic Accuracy of Multidetector CT in Detection of Early Interstitial Lung Disease With Its Role in Characterization. Recent studies have shown that multidetector CT (MDCT) thorax helps in better detection, assessment of distribution, evaluation of extent, and characterization of different findings in ILDs, increasing the confidence in the diagnosis [6,7]. Multidetector CT (MDCT) has emerged as a useful option for early diagnosis of interstitial lung disease (ILD) with adequate accuracy.
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