Abstract
To evaluate the diagnostic accuracy of computed tomography (CT)-guided percutaneous lung biopsy for solitary pulmonary nodules. Three hundred and eleven patients (211 males and 100 females), with a mean age of 59.6 years (range, 19–87 years), who were diagnosed with solitary pulmonary nodules and underwent CT-guided percutaneous transthoracic needle biopsy between January 2008 and January 2014 were reviewed. All patients were confirmed by surgery or the clinical course. The overall diagnostic accuracy and incidence of complications were calculated, and the factors influencing these were statistically evaluated and compared. Specimens were successfully obtained from all 311 patients. A total of 217 and 94 cases were found to be malignant and benign lesions, respectively, by biopsy. Two hundred and twenty-five (72.3%) carcinomas, 78 (25.1%) benign lesions, and 8 (2.6%) inconclusive lesions were confirmed by surgery and the clinical course. The diagnostic accuracy, sensitivity, and specificity of CT-guided percutaneous transthoracic needle biopsy were 92.9%, 95.3%, and 95.7%, respectively. The incidences of pneumothorax and self-limiting bleeding were 17.7% and 11.6%, respectively. Taking account of all evidence, CT-guided percutaneous lung biopsy for solitary pulmonary nodules is an efficient, and safe diagnostic method associated with few complications.
Highlights
With improved awareness of public health and the recent advances of various imaging technologies, the detection rate of solitary pulmonary nodules (SPNs) is continuously increasing, with the reported detection rate currently being 8–51% [1]
computed tomography (CT)-PTNB Is Necessary for Solitary Pulmonary Nodules differentiation of benign and malignant SPNs is critical to reducing the rate of unnecessary operations on benign SPNs, and is of utmost importance
computed tomography-guided percutaneous transthoracic needle biopsy (CT-PTNB) has been challenged by new technologies with outstanding safety results, such as electromagnetic navigation bronchoscopy (ENB) and endobronchial ultrasonography (EBUS)
Summary
With improved awareness of public health and the recent advances of various imaging technologies, the detection rate of solitary pulmonary nodules (SPNs) is continuously increasing, with the reported detection rate currently being 8–51% [1]. CT-PTNB Is Necessary for Solitary Pulmonary Nodules differentiation of benign and malignant SPNs is critical to reducing the rate of unnecessary operations on benign SPNs, and is of utmost importance. Computed tomography-guided percutaneous transthoracic needle biopsy (CT-PTNB) has represented a major approach for the diagnosis and differential diagnosis of pulmonary masses, owing to its simplicity and minimal invasiveness. CT-PTNB has been challenged by new technologies with outstanding safety results, such as electromagnetic navigation bronchoscopy (ENB) and endobronchial ultrasonography (EBUS). We cannot help but wonder if, with the constant development of new technologies, CT-guided PTNB will be replaced? To evaluate the diagnostic accuracy of CT-guided PTNB for SPN, we conducted 311 SPN patients and analysed the associated complications, and discuss the diagnostic value and safety issues of CT-PTNB in the present study
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