Abstract
ObjectiveMultiple sclerosis and major depressive disorder frequently co-occur but depression often remains undiagnosed in this population. Self-rated depression questionnaires are a good option where clinician-based standardized diagnostics are not feasible. However, there is a paucity of data on diagnostic accuracy of self-report measures for depression in multiple sclerosis (MS). Moreover, head-to-head comparisons of common questionnaires are largely lacking. This could be particularly relevant for high-risk patients with depressive symptoms. Here, we compare the diagnostic accuracy of the Beck Depression Inventory (BDI) and 30-item version of the Inventory of Depressive Symptomatology Self-Rated (IDS-SR30) for major depressive disorder (MSS) against diagnosis by a structured clinical interview.MethodsPatients reporting depressive symptoms completed the BDI, the IDS-SR30 and underwent diagnostic assessment (Mini International Neuropsychiatric Interview, M.I.N.I.). Receiver-Operating Characteristic analyses were performed, providing error estimates and false-positive/negative rates of suggested thresholds.ResultsData from n = 31 MS patients were available. BDI and IDS-SR30 total score were significantly correlated (r = 0.82). The IDS-SR30total score, cognitive subscore, and BDI showed excellent to good accuracy (area under the curve (AUC) 0.86, 0.91, and 0.85, respectively).ConclusionBoth the IDS-SR30 and the BDI are useful to quantify depressive symptoms showing good sensitivity and specificity. The IDS-SR30 cognitive subscale may be useful as a screening tool and to quantify affective/cognitive depressive symptomatology.
Highlights
Twenty-one of the 31 patients enrolled fulfilled the criteria of major depressive disorder (MDD) according to M.I.N.I. interviews
Due to screening criteria for this patient group, IDS-SR30 depression scores were slightly elevated in the patients not meeting diagnostic criteria for MDD (Table 1)
Our results indicate that two widely used patient-based instruments, the IDS-SR30 and the Beck Depression Inventory (BDI), yield good accuracy for depression in multiple sclerosis (MS) when compared to a structured clinical interview
Summary
IDS-SR30 and BDI Validation in MS-associated Depression charge, making it a useful tool for depression screening in MS
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