Abstract
The diagnostic value of membrane glycolipid biochemistry index, the lipid-bound sialic acid (LSA) and total sialic acid (TSA) in cerebrospinal fluid (CSF) was evaluated in 30 intracranial and 65 gastrointestinal tumors. The plasma LSA, TSA and red cell membrane sialic acid (R-SA) in were determined according to the method of Sevenmerhulm. Our results showed that the levels of LSA and TSA in CSF of intracranial tumor patients was higher than that of normal group(p<0.01). The concentration of TSA and LSA in patients with malignant glioma was higher than that of benign meningioma patients(P<0.01). No significance was found between intracranial halmatoma patients and normal control group for levels of membrane glycolipids (p>0.05). Results also found that the plasma LSA, TSA and R-SA of gastric carcinoma were significantly higher than those of control group (p<0.05); while no significant difference was found in the plasma LSA, TSA and R-SA levels between chronic gastritis, gastrohelcoma and normal control group (p>0.05). Plasma LSA, TSA and R-SA levels of gastric carcinoma patient were significantly higher than those of chronic gastritis patients and gastrohelcoma patients(p<0.05). It was also found that plasma LSA, TSA and R-SA contents were significantly higher in large intestine carcinoma patients than in benign in stestine tumor patients (p<0.05) while no significant difference was found between intestine benign tumor and normal control group (p>0.05). The levels of LSA, TSA and R-SA were obviously higher in the patients with metastasis than in the ones without (p<0.05.) The membrane glycolipid biochemistry index LSA and TSA in CSF are sensive markers for diagnosing intracranial tumors. For gastrointestinal malignant tumors the plasma LSA TSA and red blood cell membrane SA may be considered as auxiliary indicators for diagnosis. They can be used for distinguishing benign from malignant tumors.
Highlights
Ganglioside (GIS) is important lipid constituents of cell membranes
It was found that plasma lipid-bound sialic acid (LSA), total sialic acid (TSA) and red cell membrane sialic acid (R-sialic acid (SA)) contents were significantly higher in large intestine carcinoma patients than in benign in stestine tumor patients (p0.05)
The result of our present study is in accordance with determine of sialic acid content The levels of LSA and TSA in cerebrospinal fluid (CSF) was higher in subjects with intracranial tumor compared to normal control group, the content of TSA and LSA in subjects with malignant glioma was higher than that of subjects with benign meningioms
Summary
Ganglioside (GIS) is important lipid constituents of cell membranes. Specific change of gengliosides pattern in brain tumors reflecting tumor histoputhological origin, malignancy and progression has been extensively studied (Schiopu et al, 2009; Banda et al, 2012; Rathod et al, 2014). Little known about the value of dermination sialic acid in CSF of brain tumors, the aim of this study is to estimate the value of membrane glycolipid biochemistry index: plasma lipid-bound sialic acid (LSA), total sialic acid (TSA) and red blood cell membranes sialic acid (R-SA) in gastrointestial tumors: and to investigate the relationship between the above index and the distinguishment of benign tumors from malignant ones, tumor metastasis as well as prognosis judgement
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More From: Asian Pacific journal of cancer prevention : APJCP
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