Abstract
Objective To evaluate the diagnosis value of(1,3)-β-D-glucan antigens(G test)on patients with invasive pulmonary fungal infections(IPFI) complicated with chronic obstructive pulmonary disease(COPD).Methods The levels of(1,3)-β-D-glucan antigens in 98 high-risk of IPFI patients with COPD were detected.The sensitivity and specificity of G test was calculated.The(1,3)-β-D-glucan concentrations of fungal infection and non-fungal infection group were compared.Results At a cutoff 20 pg/ml,the sensitivity and specificity of G test for IPFI patients with COPD was 81％ and 86％.The (1,3)-β-D-glucan concentration of patients with fungal infection was significantly higher than that of patients with non-fungal infection (P ＜ 0.05).Conclusions (1,3)-β-D-glucan detection has the advantages of simple,rapid and high positive rate in diagnosis of IPFI patients with COPD.Meanwhile,G test can be used in early diagnosis for making up the deficiency of the traditional method. Key words: (1,3)-β-D-glucan antigens; Chronic obstructive pulmonary disease ; Pulmonary fungal infection
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