Abstract
Premature rupture of membranes (PROM) is sometimes difficult to diagnose. This report proposes the use of alpha-feto-protein (AFP) values in vaginal secretions for diagnostic tests. Our investigation took place in two separate phases. The first phase validated the AFP test using an immuno-enzymatic assay method and determined a threshold value from a sample of 167 female patients (Group 1: 133 patients with an extremely low probability of PROM, and Group 2: 54 patients with confirmed PROM). In the second phase the test was applied to a sample of 145 female patients (Group 3) with suspected, but unconfirmed, PROM. Results from alpha-feto-protein (AFP) evaluation were compared with data obtained from clinical, echographic and other tests. The positive/negative threshold adopted was an AFP concentration of 30 micrograms/l. For the two first groups, 1 and 2, sensitivity and specificity was in the 98% to 99% confidence level. For Group 3, sensitivity and specificity results at the 30 micrograms/l threshold value were 94.5% and 95.4% respectively. Quantitative measurement of AFP determined by immuno-enzymatic assay of vaginal secretions with a threshold of 30 micrograms/l is a reliable, simple and rapid diagnostic test. Results obtained are significantly better than the measurement of pH, the determination of prolactin, and more practical than diamino-oxidase (DAO) assays.
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