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https://doi.org/10.1186/1532-429x-14-s1-p138
Copy DOIPublication Date: Feb 1, 2012 | |
License type: CC BY 2.0 |
Summary Coronary plaque characterization at 3.0 Tesla holds great potential for clinical benefit. Coronary allograft vasculopathy (CAV) occurs after heart transplantation and is an immune-mediated diffuse coronary intimal disease. We demonstrate the use of contrast-enhanced inversion-recovery prepared coronary vessel wall MRI at 3T for diagnosis. We further validate the technique in 23 patients with intravascular ultrasound (IVUS), showing an accuracy of 91%. Direct non-invasive imaging has great potential benefit for screening and prevention in these patients. The study has further significant implications for conventional coronary atherosclerosis. Background Coronary Allograft Vasculopathy (CAV) remains the leading cause of late death after heart transplantation in children but is poorly detected by X-ray angiography. Intravascular ultrasound (IVUS) is invasive and costly, which precludes close follow-up. We have previously demonstrated the feasibility of MRI late gadolinium enhancement (LGE) in the coronary vessel wall to detect and grade CAV. The purpose of this study was to demonstrate the clinical utility of the technique and if it could be improved by imaging at 3.0 Tesla. Methods Participants underwent IVUS and cardiac MRI. Maximal intimal thickness (MIT), mean intimal index (MII = mean intimal area/ mean vessel area) and Stanford grade (0 to 4(severe)) were recorded on IVUS. MRI included a coronary magnetic resonance angiogram (CMRA) of the left coronary artery and LGE vessel wall imaging after administration of 0.2 mmol/kg Gadolinium. Participants were randomised to 3T or 1.5T (Achieva, Philips Healthcare, Best, Netherlands). 32-element cardiac phased-array receiver coils were used. The mean enhancement diameter (ED) and index (Ei= mean enhancement area/ mean vessel area on MRI) was quantified on LGE images fused with CMRA as a roadmap. Additionally, images were scored for inter/intra-observer error in analysis and image quality (0 (not seen) to 4 (sharp image)). Location of LGE on MRI and location of significant intimal thickening on IVUS were also recorded for comparison. Results
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