Diagnosis of patients with chronic kidney disease by using two fuzzy classifiers

Abstract

The feasibility of two in-house fuzzy classifiers, fuzzy rule-building expert system (FuRES) and fuzzy optimal associative memory (FOAM), for diagnosis of patients with chronic kidney disease (CKD) was investigated. A linear classifier, partial least squares discriminant analysis (PLS-DA), was used for comparison. The CKD data used in this work were taken from the UCI Machine Learning Repository. Composite datasets were created by adding different levels of proportional noise to evaluate the robustness of the two fuzzy approaches. Firstly, 11 levels of proportional noises were added to each numeric attribute of the training and prediction sets one after another, and then these simulated training and prediction sets were combined in pairs. Thus, a grid with 121 groups of simulated data was generated, and classification rates for these 121 pairs were compared. Secondly, the performances of two fuzzy classifiers using the simulated datasets, in which 11 levels of noise were randomly distributed to each numeric attribute, were compared and the average prediction rates of FuRES and FOAM were 98.1±0.5% and 97.2±1.2%, respectively, with 200 bootstrap Latin partitions. The PLS-DA can give 94.3±0.8% with the identical evaluation. Confluent datasets comprised of the original and modified datasets were also used to evaluate FuRES, FOAM, and PLS-DA classification models. The average prediction rates of FuRES and FOAM obtained from 200 bootstrapped evaluations were 99.2±0.3% and 99.0±0.3%. PLS-DA yields slightly worse accuracy with 95.9±0.6%. The results demonstrate that both FuRES and FOAM perform well on the identification of CKD patients, while FuRES is more robust than FOAM. These two fuzzy classifiers are useful tools for the diagnosis of CKD patients with satisfactory robustness, and can also be used for other kinds of patients.