Abstract
BackgroundDue to the obstruction of the surrounding structures or stiff mucosa, the primary and recurrent nonexophytic nasopharyngeal carcinoma (NE-NPC) patients are difficult to be diagnosed histologically by traditional forceps biopsy.ResultsAll the 15 cases had adequate biopsy for histological diagnosis. There were 5 cases of primary and 7 cases of recurrent NE-NPC, and 3 cases of inflammatory lesion. The histopathological diagnosis was consistent with the follow-up visit. The bleeding quantity during the CNB procedure ranged from 1 to 5 ml (mean 1.93 mL). The pain score during CNB were between 2 and 7 (mean 4.20). There were no serious complications.Materials and MethodsFrom April 2009 to March 2016, after conventional white-light and novel narrow-band imaging, nasal endoscope-guided core needle biopsy (CNB) were performed on 15 cases of nonexophytic nasopharyngeal lesion with a semiautomatic biopsy gun.ConclusionsCNB is able to get adequate biopsy specimens and thus the diagnosis accuracy of CNB is high for NE-NPC. Nasal endoscope-guided CNB is the direct approach with a short distance in the tissue before reaching the tumor. It has the advantages of minimal trauma, short operative time, and no serious complications. It is simple, safe, and worth of application in clinic.
Highlights
Nasopharyngeal carcinoma (NPC) is the most common nasopharyngeal malignancy in Southeast Asia [1]
core needle biopsy (CNB) is able to get adequate biopsy specimens and the diagnosis accuracy of CNB is high for nonexophytic nasopharyngeal carcinoma (NE-NPC)
Nasal endoscope-guided CNB is the direct approach with a short distance in the tissue before reaching the tumor
Summary
Nasopharyngeal carcinoma (NPC) is the most common nasopharyngeal malignancy in Southeast Asia [1]. The majority of NPC patients presents in the clinic with an exophytic, ulcerated mass in cavum nasopharyngeum [2]. There are still 8.8% of NPC patients have no abnormalities during conventional endoscopic examination, but present with tumor related symptoms, submucosal mass in radiological examination or positive histological results in biopsy [2]. We use the term “nonexophytic nasopharyngeal carcinoma (NE-NPC)” for this subset of NPC. Recurrent NPC is commonly seen in the parapharyngeal space, which is the difficult area for forceps biopsy. Due to the obstruction of the surrounding structures or stiff mucosa, the primary and recurrent nonexophytic nasopharyngeal carcinoma (NE-NPC) patients are difficult to be diagnosed histologically by traditional forceps biopsy
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