Diagnosis of multifocal atherosclerosis using the Celermajer test

Abstract

Aim. To study the effectiveness of determining atherosclerosis and its severity in the brachiocephalic (BCA), coronary (CA) and femoral (FA) arteries based on the endothelial function test proposed by Celermajer DS. Material and methods . The study included 216 patients: 115 men and 101 women aged 24-87 years (mean age, 61,5±10,73 years). All patients underwent coronary angiography to assess the presence and severity of coronary artery atherosclerosis, and duplex ultrasound of BCA and FA atherosclerosis. The functional activity of the endothelium was assessed using the Celermajer test. Results. Depending on the presence and severity of atherosclerosis in each arterial region (BCA, CA and FA), patients were divided into the following groups: group 1 — patients with intact arteries, group 2 — patients with moderate atherosclerosis, group 3 — patients with severe atherosclerosis. Comparative analysis of brachial artery diameters identified by the Celermajer test revealed a significant difference between the groups. Comparison of Celermajer test results in CA groups was as follows: groups 1 and 2 (p=0,34), groups 1 and 3 (p<0,0001), groups 2 and 3 (p<0,0001). The results of comparing the three BCA groups were as follows: groups 1 and 2 (p<0,05), groups 1 and 3 (p<0,001), groups 2 and 3 (p<0,001); for FA — groups 1 and 2 (p=0,008), groups 1 and 3 (p<0,0001), groups 2 and 3 (p<0,0001). Conclusion . The results showed the applicability of Celermajer test for preliminary assessment of presence and severity of atherosclerosis of BCA, CA and FA. Using Celermajer test, severe atherosclerotic lesion can be verified in all studied arterial systems. Moderate atherosclerosis of BCA and FA was also revealed. However, no reliable results were obtained for detecting moderate CA atherosclerosis with Celermajer test.