Abstract

Chromaffin-cell tumors are composed of pheochromocytomas and paragangliomas. The malignant pheochromocytomas accounting for about 10% of all pheochromocytomas. The prevalence of malignancy among paragangliomas is higher. Clinical, biochemical and histological features cannot reliably distinguish malignancy from benign tumors. Several imaging modalities have been utilized for the diagnosis and staging of these tumors. Gene expression profiling is conducted to identify a gene signature which could discriminate benign pheochromocytoma and paraganglioma from malignant ones. Key words: Chromaffin-cell tumor; Pheochromocytoma; Paraganglioma; 133/123I-MIBG; 18 F-fluorodopa PET; Gene expression profiling; ERBB-2 gene

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