Abstract
This research was aimed at investigating the artificial intelligence (AI) segmentation algorithm-based multislice spiral computed tomography (MSCT) in the diagnosis of liver cirrhosis and liver fibrosis. Besides, it was aimed at providing new methods for the diagnosis of liver cirrhosis and liver fibrosis. All patients were divided into the control group, mild liver fibrosis group, and significant liver fibrosis group. A total of 112 patients were included, with 40 cases in the mild liver fibrosis group, 48 cases in the significant liver fibrosis group, and 24 cases who underwent computed tomography (CT) examination in the control group. In the research, deconvolution algorithm of AI segmentation algorithm was adopted to process the images. The average hepatic arterial fraction (HAF) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 17.59 ± 10.03%, 18.23 ± 5.57%, and 20.98 ± 6.63%, respectively. The average MTT values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 12.69 ± 1.78S, 12.53 ± 2.05S, and 12.04 ± 1.57S, respectively. The average blood flow (BF) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 105.68 ± 15.57 mL 100 g−1·min−1, 116.07 ± 16.5 mL·100 g−1·min−1, and 110.39 ± 16.32 mL·100 g−1·min−1, respectively. Besides, the average blood volume (BV) values of patients in the control group, mild liver fibrosis group, and significant liver fibrosis group were 15.69 ± 4.35 mL·log−1, 16.97 ± 2.68 mL·log−1, and 16.11 ± 4.87 mL·100 g−1, respectively. According to statistics, the differences among the average HAF, MTT, BF, and BV values showed no statistical meaning. AI segmentation algorithm-based MSCT imaging could promote the diagnosis of liver cirrhosis and liver fibrosis effectively and offer new methods to clinical diagnosis of liver cirrhosis and liver fibrosis.
Highlights
Liver fibrosis refers to a kind of compensatory response, which is a secondary reaction in tissue repair of various forms of chronic liver damage
A total of 112 patients were included in the research, as Table 1 demonstrated. 88 patients infected by chronic hepatitis B virus were diagnosed with liver fibrosis
It was assumed that the outflow of the vein could be neglected when contrast agents passed for the first time, and tissue perfusion was obtained according to the time-density curve of the artery and tissue organ
Summary
Liver fibrosis refers to a kind of compensatory response, which is a secondary reaction in tissue repair of various forms of chronic liver damage. It is featured with the proliferation and activation of hepatic stem cells (HSC) and the excessive deposition of extracellular matrix (ECM) of intrahepatic cells [1], which were unavoidable pathological processes of the development of chronic liver diseases into liver cirrhosis [2]. Among a huge number of hepatitis B viral carriers, over 30.01 million carriers are chronic hepatitis B patients [3], and 24% of them eventually are diagnosed with liver cirrhosis and even liver cancer. With the widespread and profound studies on the pathogenesis of liver fibrosis in recent years, many scholars explicitly
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