Abstract
Purpose: In a recently published study, we developed two diagnostic models for early stage knee osteoarthritis (OA), one based on baseline clinical features alone, and one on baseline clinical and radiographic features (see Figure 1) in the CHECK cohort. In both models the outcome criterion was development of clinically relevant knee OA within 5 to 10 years, as evaluated by clinical experts. The purpose of this study was to internally and externally validate our models based diagnosis of early stage knee OA in the CHECK cohort and Osteoarthritis Initiative (OAI) incident subcohort.
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