Abstract
Disorders of lipoprotein metabolism, in conjunction with the prevalence of high-fat diets, obesity, and physical inactivity, have resulted in an epidemic of atherosclerotic disease in the United States and other developed countries. The interaction of common genetic and acquired disorders of lipoproteins with these adverse environmental factors leads to the premature development of atherosclerosis. In the United States, mortality from coronary artery disease (CAD), particularly in persons younger than 60 years, has been declining since 1970; however, atherosclerotic cardiovascular disease remains the most common cause of death among both men and women. This review contains 6 figures, 12 tables, and 47 references. Keywords: dyslipoproteinemias, hepatic lipase, hyperlipoproteinemia, hypoalphalipoproteinemia, lipoprotein,
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