Abstract

The Journal of the Ceylon College of Physicians (JCCP) is a peer-reviewed, open access journal published bi-annually by the Ceylon College of Physicians (CCP) in the last week of June and December.The objective of the Journal is to promote good clinical practice and influence policy making across the medical world through publication of original research and peer reviewed articles on current issues and to foster responsible and balanced debate on issues that affect medicine and health care in Sri Lanka. Contributions to the JCCP reflect its national and multidisciplinary readership and include current thinking across a range of medical specialties.

Highlights

  • The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has imposed a major burden on the healthcare sector in most countries including Sri Lanka

  • This review summarises the investigations used at present for diagnosis of SARSCoV-2 infection, their applicability and the newer tests in the pipeline

  • The N-antigen detection rapid kit developed by Diao et al which takes 10 minutes to perform providing a quick method of viral protein detection had a sensitivity of 68% in the tested samples when the reverse transcriptase polymerase chain reaction (RT-PCR) of NP swab was taken as the reference standard[14]

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Summary

Introduction

The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has imposed a major burden on the healthcare sector in most countries including Sri Lanka. Available data suggest that infected persons shed the virus from their respiratory tracts beginning in the late-incubation period until recovery allowing RTPCR performed on a relevant sample to detect viral nucleic acid early in the course of the disease[8]. A) Self-enclosed rapid molecular assay systems: ID NOWTM (Abbott), cobas® Liat® (Roche), BioFire FilmArray (bioMérieux) and GeneXpert® (Cepheid) have a self-enclosed system which has integrated the RNA extraction, amplification and detection in to a cartridge[1,9] Simple workflow of these assays allow minimal sample handling and does not require an intensive training for the laboratory technicians. The N-antigen detection rapid kit developed by Diao et al which takes 10 minutes to perform providing a quick method of viral protein detection had a sensitivity of 68% in the tested samples when the RT-PCR of NP swab was taken as the reference standard[14]

The use of serological assays
Clinical samples recommended for diagnostic testing
Overcoming the challenges
Findings
Conclusion
Full Text
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