Abstract
In this issue of the Journal of Cystic Fibrosis, five separate articles provide new insights into the challenges and evolution of diagnosing cystic fibrosis (CF). The first descriptions of CF as a distinct clinical entity were independently reported in the 1930s by Andersen in the USA and Fanconi in Switzerland [1, 2]. At that time, the diagnosis of CF was made based on a set of phenotypic features, primarily exocrine pancreatic insufficiency and suppurative lung disease. Subsequent work in the 1950s by Di Sant'Agnese, Gibson, and Cooke led to the identification of sweat electrolyte abnormalities in people with CF and the measurement of sweat chloride as a diagnostic test for CF [3, 4].
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