Abstract
Abstract δ-Aminolevulinic acid and porphobilinogen were identified in urine from a patient with acute intermittent porphyria on routine amino acid chromatography. The compounds were well and rapidly separated by a two-dimensional combination of high-voltage, thin-layer electrophoresis and chromatography. Both compounds gave a yellowish color with ninhydrin; the porphobilinogen gave a strong red color when Ehrlich’s reagent was then applied. Such a pattern has not been observed in any blood and urinary amino acid chromatograms from over 900 patients with other conditions, who were receiving a variety of drugs. We consider this a rapid, specific diagnostic aid in cases of acute intermittent porphyria.
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