Abstract
Tumor induced osteomalacia (TIO) is an acquired metabolic bone disease caused by tumors secreting high concentration of phosphatonins such as fibroblast growth factor-23(FGF-23), resulting in renal phosphate wasting. The tumors are derived from mesenchymal tissue in bone or soft tissues, and always located in obscure tissues. Clinical manifestations include progression of bone pain, activity limitation, muscle weakness, etc. Bone X-ray films show lower bone mineral density and fuzzy bone trabecular. Patients with TIO always look for medical care in various departments because of these complex manifestations. As a result, the rates of misdiagnosis and mistreatment are high previously. With multiple qualitative and positioning inspection, this disease can be clearly diagnosed and cured after tumor complete resection. Key words: Tumor induced osteomalacia; Metabolic bone disease; Pathological fractures; Mesenchymal tissue tumor; Somatostatin
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