Abstract
We studied psychovegetative status and efficacy of Afobazol for correction of psychovegetative disorders and prevention of adverse effects of antituberculosis drugs in patients with newly diagnosed tuberculosis. The study involved 98 patients: 49 patients received antituberculosis therapy and Afobazol (the 1st group) and 49 patients were treated with antituberculosis medications only (the 2nd group). We found that 100 % of newly diagnosed tuberculosis patients had psychovegetative disorders with imbalance in all components of the vegetative nervous system, hyperactivity of the sympathetic component and high levels of somatic and psychic anxiety. Antituberculosis chemotherapy enhances psychovegetative disorders. Addition of anxiolytic drug Afobazol to the antituberculosis therapy improved results of the treatment probably due to improvement in the vegetative nervous function, alleviation of psychic disorders and increase tolerability of antituberculosis therapy.
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