DIAGNOSIS AND TREATMENT OF PRIMARY MINOR IMMUNODEFICIENCIES IN PATIENTS WITH RECURRENT UROGENITAL INFECTIONS AND IMMUNE-DEPENDENT INFERTILITY

Abstract

It has now been established that immunosuppressive status is observed in patients with recurrent urogenital infections caused by opportunistic and low virulent microflora. A pooled analysis of the known prevalence rates of the 30 currently known mild human immune dysfunctions suggests that at least 20% of the current population (in one in five people) is currently affected by at least one primary minor immunodeficiency. This contradicts the established but erroneous view of the rarity of primary immunodeficiencies in humans.Therefore, the diagnosis of primary minor immunodeficiencies should be an integral part of modern routine medical practice of specialists in various fields. This article presents the classification of minor primary human immunodeficiencies, considers the differences between major and minor immune dysfunctions, as well as the algorithm of clinical diagnosis of primary minor immunodeficiencies and modern approaches to treatment.Detection of genetically determined disease of the immune system can not only explain the atypical course of opportunistic or low virulent infections of the urogenital tract and reduced fertility, but can also open the way to the appointment of targeted immunotherapy to compensate for the causative immunodeficiency. This can take the effectiveness of the applied interventions to a qualitatively new level, solving even severe clinical problems.