Diagnosis and treatment of Leydig cell tumors

Abstract

Tumors of the testes not originating from germinal epithelium are arare entity and represent adiagnostic and therapeutic challenge. Leydig cell tumors (LCT) are rare stromal tumors of the testis. To present current approaches in diagnostic and treatment of LCT. A literature search in PubMed was performed and the currently available guidelines concerning LCT were evaluated. Articles and book chapters were selected based on relevance to daily practice. The low incidence of Leydig cell tumors not originating from the germinal epithelium, but from the stroma of the testis requires astandardized approach to determine relevant differential diagnosis and to optimize diagnosis and treatment depending on the current standard of knowledge and to determine whether it is benign or malignant. While more than 90% of LCT are benign and treatment is only restricted to the testis, malignant subtypes require radical surgical resection of the testicular and metastatic sites. Astandardized diagnostic and therapeutic approach as well as aprospective registry of rare LCT could facilitate further detailed analysis to improve the understanding of tumor biology resulting in optimized therapeutic guidelines including follow-up strategies.