Abstract
Background Penicillin allergy is a common presentation in allergy clinic. The diagnosis of immediate hypersensitivity is made using clinical history, skin testing, specific IgE levels and oral challenge. Skin testing is done using benzyl penicilloyl-polylysine (PPL) and a minor determinant mixture (MDM) consisting of penicillin byproducts. Although using PPL and MDM is considered first line for diagnosis [1], our clinic is unable to consistently obtain MDM. We have undertaken a retrospective chart review to assess our current protocol in diagnosing penicillin allergy using Penicillin G (PG) alone instead of MDM.
Highlights
Penicillin allergy is a common presentation in allergy clinic
We have undertaken a retrospective chart review to assess our current protocol in diagnosing penicillin allergy using Penicillin G (PG) alone instead of minor determinant mixture (MDM)
9% of patients with positive oral challenge had negative testing with MDM compared to 3% with PG
Summary
Diagnosing penicillin allergy in the absence of minor determinant mixture Lana Rosenfield1*, Chrystyna Kalicinsky, Richard Warrington. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2014 Ottawa, ON, Canada. 23-26 October 2014
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