Abstract
The RhD (Rh0[D]) antigen is considered the most immunogenic of the antigens found on the surface of the human red cell. In 1941, Levine, Katzin, and Burham1 showed that antibodies to the RhD antigen in pregnant women caused hemolysis and anemia in their offspring. Originally called erythroblastosis fetalis secondary to the finding of a large number of immature red cells in the neonatal circulation, today this condition is known as hemolytic disease of the fetus and newborn.When RhD-positive fetal cells enter the maternal circulation as a result of pregnancy-related events such as miscarriage or delivery, anti-D antibody . . .
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