Abstract
The often-encountered allergic reaction of unknown etiology can be a perplexing diagnostic conundrum in any clinical environment. Alpha-gal syndrome is an allergic reaction to mammalian meat consumption that occurs after the bite of certain hard ticks, mites, or chiggers. This potentially lethal allergic reaction is the result of an immunoglobulin E antibody response to a certain carbohydrate found in almost all mammalian meats and meat products. Epidemiologically, alpha-gal has been observed worldwide, but in the United States the prevalence is higher in the southeastern states because of the common hard tick vector known as the lone star tick. Providers should be aware of the recent scientific information available to assist clinicians at the point of care with diagnosis and treatment.
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