Abstract

Eosinophils are leukocytes involved in a variety of disease states, including atopic processes, drug reactions, and immunodeficiency syndromes.1,2 Although there are exceptions, for most conditions, the relationship between these cells, their abundance, and the underlying pathophysiology of disease is poorly understood and primarily speculative. There is great potential benefit in early detection and diagnosis of eosinophil-associated disease, given many are significantly steroid responsive, and newer therapies such as anti-interleukin 5 and anti–interleukin 5 receptor monoclonal antibodies have been found to be effective in several eosinophil-associated diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndromes.

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