Abstract
P 1P 6-di(adenosine-5′)hexaphosphate (Ap 6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap 6A on guinea-pig cardiac ATP-sensitive K + (K ATP) channels. When applied to the intracellular side of excised membrane patches, Ap 6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of K ATP channel activity. We conclude that Ap 6A is a potent inhibitory ligand of K ATP channels.
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