Abstract
BackgroundPreviously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.MethodsBlood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.ResultsIn men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L).ConclusionThe d-ROMs test may provide a useful indicator of nAMD in men but not in women.
Highlights
We showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration than in those without Age-related macular degeneration (AMD)
Advanced AMD is classified according to its pathophysiology as either neovascular AMD or geographic atrophy (GA) [3]. neovascular age-related macular degeneration (nAMD) is characterized by choroidal neovascularization (CNV) and an increase in intraretinal/subretinal fluid, which is strongly associated with the overexpression of vascular endothelial growth factor (VEGF)
Correlations between serum Diacron reactive oxygen metabolites (d-Reactive oxygen metabolites (ROM)) levels and nAMD patient characteristics We evaluated correlations between d-ROM levels and age, logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), and CNV area separately for the male and female nAMD patients
Summary
We showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. We showed that serum malondialdehyde (MDA), a marker of oxidative stress, was significantly higher in patients with nAMD than in those without AMD, and that there was a significant correlation between serum MDA levels and the area of CNV [12]. The Diacron reactive oxygen metabolites (d-ROMs) test for measuring reactive oxygen metabolites (ROMs) in blood has been used for various biological and medical purposes [13, 14]. This test uses the Free Radical Analytical System (Diacron International, Grosseto, Italy) [15,16,17]. Despite its power as an oxidant, Matsuura et al BMC Ophthalmology (2020) 20:56
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