Abstract
The inhibition of nucleolar RNA synthesis in HeLa cells by acridines as well as by a series of 9-NH 2 diacridines, connected through their 9-NH 2 groups by hydrocarbon chains from (CH 2) 2 to (CH 2) 12, and by the polyamine chains spermidine and spermine, has been investigated. Nucleolar RNA synthesis in HeLa cells is most sensitive to the longer chain diacridines, indicating that double intercalation may be essential for their action. These data are in agreement with the action in vitro of these compounds. However, if the degree of inhibition of nucleolar rRNA synthesis is related to the nuclear uptake, the single intercalators appear to be more effective inhibitors.
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