Abstract
Objective: The study's main goal is to develop a suitable niosomes (NS) encapsulated drug for anti-inflammatory effects such as diacerein (DC) and to evaluate the system's vesicle size (VS), entrapment efficiency (EE %), physical stability and in vitro release. Methods: Tween (40 and 60), cholesterol, and stearylamine were used in a 1:1:0.1 molar ratios as non-ionic surfactants. Thin film hydration was used to create the NS. Results: The higher EE% was observed with NS (F11) prepared from tween 60, cholesterol and 2.5 min sonication. These formulations' release patterns were Higuchi diffusion and first order. For the stability study, NS formulations were stored at temperature between 2-8 °C for 60 d retains the most drugs when compared to room and high temperature conditions. Conclusion: The findings of this study have conclusively shown that after NS encapsulation of DC, drug release is prolonged at a constant and controlled rate.
Highlights
ResultsThe higher EE% was observed with NS (F11) prepared from tween 60, cholesterol and 2.5 min sonication
To obtain a stable blood or tissue level that is therapeutically both effective and nontoxic for extended periods of time, the drug therapy's foremost goal is to reach a certain blood or tissue level
Lamellar structures formed by a non-ionic surfactant, cholesterol and stearylamine mixed together and hydrated in water are known as vesicles and called NS or non-ionic surfactants [5]
Summary
The higher EE% was observed with NS (F11) prepared from tween 60, cholesterol and 2.5 min sonication. These formulations' release patterns were Higuchi diffusion and first order. NS formulations were stored at temperature between 2-8 °C for 60 d retains the most drugs when compared to room and high temperature conditions
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