Abstract
Objectives: Diabetes mellitus has been shown to be an independent risk factorfor hepatocellular carcinoma in populations at risk. Different anti-diabetic drugs have beenshown to have different effects on incidence of cancers in diabetic patients. Data Source:Outpatient and inpatient hospital records as well as fresh cases. Design of Study: Hospitalbased retrospective case control study. Setting: DHQ, Sargodha. Period: Fifteen years (10years retrospective, 5 years prospective, from the starting date of study). Materials & Methods:In a hospital based study we recorded the incidence of HCC in patients otherwise consideredto be at risk. We also observed whether anti-diabetic monotherapy has any effects on HCCoccurrence in our target population. Results: We found out that incidence of HCC in diabeticpatients with a concomitant HBV or HCV infection was at least 1.5 times higher than non-diabetichepatitis patients. The incidence of HCC reduced in patients using metformin as compared tosulfonylureas. Conclusion: Diabetes is an independent risk factor for hepatocellular carcinomaand metformin use is correlated with reduced HCC occurrence in risk groups.
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