Abstract
Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS measurement points were analyzable. For TCP, SCP and DCP, the leakage did not decrease RS at points where FD was maintained. The greater the leakage, the smaller the RS reduction at points with low FD in TCP (P = .020). Points with high leakage showed a significant smaller RS reduction than points with low leakage (P = .001 for TCP, P = .040 for SCP, and P = .046 for DCP) only in areas with low RT and low FD. Our results suggested that vascular hyperpermeability may inhibit the RS reduction in the non-edematous ischemic diabetic retina.
Highlights
Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in Diabetic retinopathy (DR)
FD values in the TCP, SCP and DCP were significantly correlated with RS in our study (Fig. 1)
Leakage did not impact the correlation in the DCP, but the correlation between FD and RS tended to be weaker in the high-leakage group than in the low-leakage group for TCP and SCP
Summary
Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. Prolonged edema due to enhanced vascular permeability promotes impairment of visual function[13], our results suggest that leakage may inhibit the RS reduction in the non-edematous ischemic retina in patients with DR. RS was measured in the upper or lower temporal area of the macula (a 3 × 3-mm square with 25 points/patient; see Step 1, Supplemental Figure 1, which demonstrates FD calculation and leakage evaluation).
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