Diabetic vascular calcification and abnormal bone metabolism: the relation between bone and vascular

Abstract

High-frequency severe atherosclerosis/calcinosis is observed in diabetes mellitus and chronic dialysis, which leads to cardiovascular events. However, the effective treatment for suppressing the progression of vascular calcification has not been established. Here we review the mechanism of vascular calcification and present our findings that a first generation of bisphosphonate is useful in prevention of vascular calcification in diabetes and chronic renal failure.